Coilin,Coilin蛋白抗体

产品编号HZ-14645R
英文名称Coilin
中文名称Coilin蛋白抗体
别 名CLN 80; CLN80; COIL; COIL_HUMAN; Coilin; coilin p80; p80; P80 coilin，
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
Coilin,Coilin蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36, 63kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Coilin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Coilin,Coilin蛋白抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

Function:
Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Subcellular Location:
Nucleus. Nuclear coiled body located in the interchromatin space between the nucleolus and the nucleus.

Tissue Specificity:
Found in all the cell types examined.

Similarity:
Belongs to the coilin family.

Gene ID:
8161

Database links:
Entrez Gene: 8161 Human
Entrez Gene: 12812 Mouse
Entrez Gene: 50998 Rat
Omim: 600272 Human
SwissProt: P38432 Human
SwissProt: Q5SU73 Mouse
Unigene: 532795 Human
Unigene: 268004 Mouse
Unigene: 203468 Rat

Coilin,Coilin蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.