FITC标记的Wnt1信号通路蛋白3抗体
产品名称： FITC标记的Wnt1信号通路蛋白3抗体
英文名称： Anti-WISP3/FITC
产品编号： HZ-12380R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-WISP3/FITC Conjugated antibody
FITC标记的Wnt1信号通路蛋白3抗体
| 英文名称 | Anti-WISP3/FITC |
| 中文名称 | FITC标记的Wnt1信号通路蛋白3抗体 |
| 别 名 | CCN 6; CCN family member 6; CCN6; CYR61; LIBC; Lost in inflammatory breast cancer tumor suppressor protein; MGC125987; MGC125988; MGC125989; OTTHUMP00000040421; PPAC; PPD; UNQ462/PRO790/PRO956; WISP 3; WISP-3; WISP3; WISP3_HUMAN; WNT 1 inducible signaling pathway protein 3; Wnt 1 signaling pathway protein 3; WNT1 inducible signaling pathway protein 3; WNT1 inducible signaling pathway protein 3 precursor; WNT1-inducible-signaling pathway protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, Monkey, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human WISP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Wnt-induced secreted protein (WISP)-1, WISP-2 and WISP-3 are members of the CCN family of growth factors, which include connective tissue growth factor (CTGF) and Cyr61. WISP-1, WISP-2 and WISP-3 share significant sequence similarity, including four conserved cysteine-rich domains, and they are believed to function as dimers in their active forms. WISP-1 expression is observed in various tissues including adult heart, kidney and spleen, while WISP-2 expression predominates in skeletal muscle, colon and ovary. Both WISP-1 and WISP-2 are upregulated in cells transformed with the proto-oncogene Wnt-1, and they are also more highly expressed in human colon tumors, suggesting that these proteins may participate in tumor development. WISP-3 is involved in normal post-natal skeletal growth, and it is also implicated in the development of the autosomal recessive skeletal disorder progressive pseudorheumatoid dysplasia, which affects cartilage homeostasis by disrupting the growth of chondrocyte and normal cell columnar organization. Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Subcellular Location: Secreted. Tissue Specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes. DISEASE: Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]. PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Similarity: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Database links: Entrez Gene: 8838 Human Entrez Gene: 327743 Mouse Entrez Gene: 499461 Rat Omim: 603400 Human SwissProt: O95389 Human SwissProt: D3Z5L9 Mouse Unigene: 558428 Human Unigene: 208111 Mouse Unigene: 141375 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Wnt诱导的分泌蛋白（WISP）- 1，WISP-2和WISP-3是生长因子CCN家族成员，包括结缔组织生长因子（CTGF）和CYR61。WISP-1、WISP-2和WISP-3具有显著的序列相似性，包括四个保守的富含半胱氨酸的结构域，并且它们被认为在它们的活性形式中起二聚体的作用。WISP-1在成人心脏、肾脏和脾脏等组织中均有表达，WISP-2在骨骼肌、结肠和卵巢中的表达占优势。Wist-1和WISP-2均在原癌基因Wnt-1转化的细胞中上调，它们在人结肠肿瘤中的表达也更高，提示这些蛋白可能参与肿瘤的发育。WISP-3参与正常出生后骨骼生长，也参与常染色体隐性骨骼疾病进行性假性类风湿异型增生，通过破坏软骨细胞和正常细胞柱状组织的生长影响软骨内环境稳定。n.名词