TLR4 polyclonal antibody
产品名称： TLR4 polyclonal antibody
英文名称： TLR4 polyclonal antibody
产品编号： PAB15432
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
- Immunogen:
- A synthetic peptide corresponding to amino acids 420-435 of human TLR4.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- Detects ~75-80KDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.05% BSA, sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-3 ug/mL)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B.Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2163-7.
- 2.
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.Immunity. 1999 Oct;11(4):443-51.
- 3.
- The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).
Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A.J Exp Med. 1998 Jun 15;187(12):2097-101.
- Entrez GeneID:
- 7099
- Gene Name:
- TLR4
- Gene Alias:
- ARMD10,CD284,TOLL,hToll
- Gene Description:
- toll-like receptor 4
- Omim ID:
- 603030
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022807,homolog of Drosophila toll
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