FITC标记的肿瘤血管内皮标志物/G蛋白偶联受体124抗体
产品名称： FITC标记的肿瘤血管内皮标志物/G蛋白偶联受体124抗体
英文名称： Anti-GPR124/FITC
产品编号： HZ-13515R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR124/FITC Conjugated antibody
FITC标记的肿瘤血管内皮标志物/G蛋白偶联受体124抗体
| 英文名称 | Anti-GPR124/FITC |
| 中文名称 | FITC标记的肿瘤血管内皮标志物/G蛋白偶联受体124抗体 |
| 别 名 | DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; GPR124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor; GPCR GPR124. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 G蛋白偶联受体 细胞类型标志物 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 139kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor 124 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies. Function: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Subunit: Interacts with DLG1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 25960 Human Entrez Gene: 306543 Rat Omim: 606823 Human SwissProt: Q96PE1 Human Unigene: 274136 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肿瘤内皮标志物（TEM）在血管生成和新血管生成过程中广泛表达于人实体瘤的血管中。这些包括TEM1（Endosialin）、TEM5（G蛋白偶联受体124）和TEM7（丛蛋白域1）。在正常人和小鼠组织中，TEMS与低水平的细胞表面膜相关。TEM5是一个七遍跨膜受体，而TEM1、TEM7和TEM8跨越膜一次。TEM5表达在肿瘤血管生成和新生血管生成过程中升高。TEM7在肿瘤血管内皮细胞和神经元中高表达。因此，TEM5和TEM7可能是抗血管生成治疗的合适靶点。