FITC标记的成纤维细胞生长因子受体底物2抗体
产品名称： FITC标记的成纤维细胞生长因子受体底物2抗体
英文名称： Anti-FRS2/FITC
产品编号： HZ-6913R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FRS2/FITC Conjugated antibody
FITC标记的成纤维细胞生长因子受体底物2抗体
| 英文名称 | Anti-FRS2/FITC |
| 中文名称 | FITC标记的成纤维细胞生长因子受体底物2抗体 |
| 别 名 | FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast Growth Factor Receptor Substrate 2; FRS 2; FRS2_HUMAN; FRS2A; FRS2alpha; SNT 1; SNT; SNT-1; SNT1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 生长因子和激素 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FRS2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Subunit: Contains 1 IRS-type PTB domain. Subcellular Location: Endomembrane system. Cytoplasmic, membrane-bound. Tissue Specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Post-translational modifications: Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. Similarity: Contains 1 IRS-type PTB domain. Database links: Entrez Gene: 10818 Human Entrez Gene: 327826 Mouse Entrez Gene: 314850 Rat Omim: 607743 Human SwissProt: Q8WU20 Human SwissProt: Q8C180 Mouse Unigene: 593446 Human Unigene: 135965 Mouse Unigene: 22182 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
将FGR和NGF受体连接到下游信号通路的接头蛋白。涉及MAP激酶的激活。通过竞争NTRK1上的共同结合位点来调节信号通过SHC1。