BRD2,BRD2蛋白抗体

产品编号HZ-12888R
英文名称BRD2
中文名称BRD2蛋白抗体
别 名BRD 2; Brd2; BRD2_HUMAN; Bromodomain containing 2; BROMODOMAIN CONTAINING PROTEIN2; Bromodomain-containing protein 2; D6S113E; DKFZp686N0336; female sterile homeotic related gene 1; FLJ31942; FSH; FSRG1; KIAA9001; NAT; O27.1.1; Really interesting new gene 3 protein; Ring3; RING3 PROTEIN; RNF3.
说 明 书0.1ml 0.2ml
研究领域信号转导 激酶和磷酸酶 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
BRD2,BRD2蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BRD2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BRD2,BRD2蛋白抗体PubMedPubMed
产品介绍background:
The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed.

Function:
May play a role in spermatogenesis or folliculogenesis.

Subunit:
Homodimer. Interacts with E2F1 and with histone H4acetylated at 'Lys-13'.

Subcellular Location:
Nucleus.

BRD2,BRD2蛋白抗体Similarity:
Contains 2 bromo domains.
Contains 1 ET domain.

Gene ID:
6046

Database links:
Entrez Gene: 6046 Human
Entrez Gene: 14312 Mouse
Entrez Gene: 294276 Rat
Omim: 601540 Human
SwissProt: P25440 Human
SwissProt: Q7JJ13 Mouse
SwissProt: Q6MGA9 Rat
Unigene: 75243 Human
Unigene: 3444 Mouse
Unigene: 98146 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.