FITC标记的甲状腺受体相互作用蛋白8抗体
产品名称： FITC标记的甲状腺受体相互作用蛋白8抗体
英文名称： Anti-JMJD1C/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-JMJD1C/FITC Conjugated antibody
FITC标记的甲状腺受体相互作用蛋白8抗体
| 英文名称 | Anti-JMJD1C/FITC |
| 中文名称 | FITC标记的甲状腺受体相互作用蛋白8抗体 |
| 别 名 | JHD2C_HUMAN; Jmjd1c; Jumonji domain containing 1C; Jumonji domain-containing protein 1C; Probable JmjC domain-containing histone demethylation protein 2C; Thryoid receptor interacting protein; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 284kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JMJD1C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: JMJD1C is a nuclear protein that belongs to the JHDM2 family of histone demethylases. Expressed in a wide variety of tissues, JMJD1C binds iron as a cofactor and contains one JMJC domain, a TRI8H1 domain with a C2HC4-type zinc finger-like motif and a TRI8H2 domain with a TR∫ (thyroid hormone receptor ∫)-binding region. JMJD1C demethylates lysine-9 of Histone H3, thereby playing a central role in the histone code and participating in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1C plays an important role in the regulation of cell growth during development and in chromatin regulation. Due to alternative splicing events, two isoforms exist for JMJD1C. One of these isoforms functions as a coactivator for the AR (androgen receptor). Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain. Database links: Entrez Gene: 221037 Human Entrez Gene: 108829 Mouse Entrez Gene: 171120 Rat NCBI: NP_004232.2 Human Omim: 604503 Human SwissProt: Q15652 Human SwissProt: Q69ZK6 Mouse SwissProt: Q6NV48 Mouse Unigene: 413416 Human Unigene: 499821 Human Unigene: 23846 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
JMJD1C是属于组蛋白去甲基化酶的JHDM2家族的核蛋白。在多种组织中表达，JMJD1C结合铁作为辅因子，包含一个JMJC结构域，一个具有C2HC4型锌指状基序的Tr8H1结构域和一个具有TR（甲状腺受体）结合区的Tr8H2结构域。JMJD1C去甲基化组蛋白H3的赖氨酸-9，从而在组蛋白编码中起核心作用，参与基于核激素受体的转录调控。此外，JMJD1C在发育和染色质调节中对细胞生长的调节起着重要作用。由于选择性剪接事件，JMJD1C存在两种亚型，这些异构体之一是AR（雄激素受体）的共激活剂。