EIF2D,EIF2D蛋白抗体

产品编号HZ-14539R
英文名称EIF2D
中文名称EIF2D蛋白抗体
别 名Eukaryotic translation initiation factor 2D; HCA56; Hepatocellular carcinoma associated antigen 56; Hepatocellular carcinoma-associated antigen 56; LGTN; LIGA_HUMAN; Ligatin; OTTHUMP00000034537; OTTHUMP00000034538.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 转运蛋白 细胞粘附分子 细胞分化 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow,
EIF2D,EIF2D蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EIF2D
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EIF2D,EIF2D蛋白抗体PubMedPubMed
产品介绍background:
HCA56 is a 584 amino acid peripheral membrane protein belonging to the ligatin family. Expressed during embryonic development and in early differentiated states, ligatin is a trafficking receptor for phosphoglycoproteins. Ligatin localizes to phosphoglycoproteins within endosomes and at the cell periphery where it participates in specific metabolic processes as well as intercellular adhesion. Involved in RNA binding and translation initiation through its single PUA domain and SUI1 domain, ligatin is down-regulated with long-lasting effects by the activation of Ca2+ dependent N-methyl-D-aspartate (NMDA) subclass of excitatory amino acid (EAA) receptors. Ligatin is considered a marker protein for membrane-vesicle transport systems. Ligatin exists as two alternatively splice variants and is encoded by a gene located on human chromosome 1.

Function:
Trafficking receptor for phosphoglycoproteins. Localizes phosphoglycoproteins within endosomes and at the cell periphery where they participate in specific metabolic processes as well as intercellular adhesion.

Subcellular Location:
Membrane.

Tissue Specificity:

DISEASE:

Similarity:
Belongs to the ligatin family.
Contains 1 PUA domain.
Contains 1 SUI1 domain.

Gene ID:
1939

EIF2D,EIF2D蛋白抗体Database links:
Entrez Gene: 1939 Human
Omim: 151625 Human
SwissProt: P41214 Human
Unigene: 497581 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.