FITC标记的神经元衍生孤儿受体1抗体
产品名称： FITC标记的神经元衍生孤儿受体1抗体
英文名称： Anti-NOR1/FITC
产品编号： HZ-11903R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NOR1/FITC Conjugated antibody
FITC标记的神经元衍生孤儿受体1抗体
| 英文名称 | Anti-NOR1/FITC |
| 中文名称 | FITC标记的神经元衍生孤儿受体1抗体 |
| 别 名 | CHN; Chondrosarcoma, extraskeletal myxoid, fused to EWS; CSMF; MINOR; Mitogen induced nuclear orphan receptor; Mitogen-induced nuclear orphan receptor; Neuron derived orphan receptor 1; Neuron derived orphan receptor; Neuron-derived orphan receptor 1; NOR1; Nr4a3; NR4A3_HUMAN; Nuclear hormone receptor NOR-1; Nuclear hormone receptor NOR1; Nuclear receptor subfamily 4 group A member 3; TEC; Translocated in extraskeletal chondrosarcoma. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NOR1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nur77 (also designated NGFI-B), Nurr1 (Nur-related factor 1), and NOR-1 (neuron-derived orphan receptor 1) constitute the NGFI-B subfamily within the nuclear receptor superfamily. Ligands for these protein have not been identified, and, therefore, they are designated “orphan nuclear receptors”. Genes of the NGFI-B subfamily are classified as immediate-early genes, which are induced rapidly, but transiently, in response to a variety of stimuli. They have been implicated in cell proliferation, differentiation, and apoptosis. The human NOR-1 gene maps to chromosome 9q, and encodes a protein which is expressed in heart, skeletal muscle, thymus, and spleen as well as in brain, where it is developmentally regulated. There-fore, NOR-1 may be involved in regulating neural differentiation. The NOR-1 gene also undergoes chromosomal translocation with the EWS gene to produce a protein thought to affect pre-mRNA splicing. Function: Binds to the B1A response-element. Subcellular Location: Nucleus. Tissue Specificity: Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta. DISEASE: Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 8013 Human Entrez Gene: 18124 Mouse Entrez Gene: 397479 Pig Entrez Gene: 58853 Rat Omim: 600542 Human SwissProt: Q92570 Human SwissProt: Q9QZB6 Mouse SwissProt: P51179 Rat Unigene: 279522 Human Unigene: 247261 Mouse Unigene: 62694 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
因此Nur77，Nurr1指定段与（B）只有相关因子1），和NOR - 1（神经来源孤儿受体1）构成一段与B subfamily在核受体超家族。从配体的蛋白没有被发现，和，因此，他们在指定的孤儿核受体。subfamily段与B基因的品种为即刻早期基因，这是诱导迅速，但transiently，回应各种刺激。他们已经implicated在细胞增殖，分化和凋亡。人类基因映射到染色体的NOR - 1蛋白和encodes为A，这是表达在心脏，骨骼肌，脾，胸腺，脑，和工作人员的第一，它是调节。有纺、NOR - 1可能是参与调节神经分化。的NOR - 1基因的染色体易位与EMS因此undergoes A蛋白基因产生影响前体mRNA剪接的一个思想。