SELPLG monoclonal antibody, clone 3E2.25.5
产品名称: SELPLG monoclonal antibody, clone 3E2.25.5
英文名称: SELPLG monoclonal antibody, clone 3E2.25.5
产品编号: MAB5327
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native SELPLG.
- Immunogen:
- Native purified SELPLG from human neutrophils.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes the human CD162 cell surface glycoprotein, a 120kD molecule also known as P-Selectin Glycoprotein Ligand I (PSGL-1). CD162 is the major counter receptor for P-selectin and is involved in neutrophil attachment and rolling to endothelium. In peripheral blood CD162 is expressed by monocytes, granulocytes, T cells and some B cells. This antibody is a blocking antibody, inhibiting PSGL-1 and P-selectin interaction.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Functional Study
- Entrez GeneID:
- 6404
- Gene Name:
- SELPLG
- Gene Alias:
- CD162,CLA,PSGL-1,PSGL1
- Gene Description:
- selectin P ligand
- Omim ID:
- 600738
- Gene Ontology:
- Hyperlink
- Gene Summary:
- SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. [provided by RefSeq
- Other Designations:
- cutaneous lymphocyte-associated associated antigen
- Gene Pathway
- Related Disease
- Antiphospholipid Syndrome
- Atherosclerosis
- Atherosclerosis
- Birth Weight
- Cardiovascular Diseases
- Cerebrovascular Accident
- Coronary Artery Disease
- Coronary Disease
- Coronary Restenosis
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- Hemorrhagic Disorders
- Inflammation
- Ischemia
- Leukemia
- Leukemia, Myeloid, Acute