肿瘤抑制基因PHLPP抗体-抗体-抗体-生物在线
北京索莱宝科技有限公司
肿瘤抑制基因PHLPP抗体

肿瘤抑制基因PHLPP抗体

商家询价

产品名称: 肿瘤抑制基因PHLPP抗体

英文名称: PHLP

产品编号: bs-5812R

产品价格: null

产品产地: 北京

品牌商标: BIOSS

更新时间: 2024-06-07T08:51:26

使用范围: WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,

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Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.