FITC标记的凝集胎盘蛋白1抗体
产品名称： FITC标记的凝集胎盘蛋白1抗体
英文名称： Anti-COLEC12/FITC
产品编号： HZ-10736R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-COLEC12/FITC Conjugated antibody
FITC标记的凝集胎盘蛋白1抗体
| 英文名称 | Anti-COLEC12/FITC |
| 中文名称 | FITC标记的凝集胎盘蛋白1抗体 |
| 别 名 | Collectin placenta protein 1; Collectin placenta 1; Collectin-12; hCL-P1; CL-P1; Nurse cell scavenger receptor; Scavenger receptor with C-type lectin; Scavenger receptor class A member 4; COLEC12; CLP1; NSR2; SCARA4; SRCL. COL12_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COLEC12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Colec12 is a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Colec12 is a scavenger receptor that displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast and mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide. Subcellular Location: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface. Tissue Specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. Similarity: Contains 1 C-type lectin domain. Contains 3 collagen-like domains. Database links: Entrez Gene: 421061 Chicken Entrez Gene: 504741 Cow Entrez Gene: 81035 Human Entrez Gene: 140792 Mouse Entrez Gene: 361289 Rat Omim: 607621 Human SwissProt: Q2LK54 Chicken SwissProt: A6QP79 Cow SwissProt: Q5KU26 Human SwissProt: Q8K4Q8 Mouse SwissProt: Q4V885 Rat Unigene: 33741 Chicken Unigene: 4492 Cow Unigene: 464422 Human Unigene: 218571 Mouse Unigene: 31273 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
COLEC12是C-凝集素家族的成员，具有胶原样序列和碳水化合物识别结构域的蛋白质。COLEC12是一种清道夫受体，显示与宿主防御相关的多种功能。它促进革兰氏阳性、革兰氏阴性细菌和酵母的结合和吞噬，并介导血管内皮细胞对氧化修饰的低密度脂蛋白（oxLDL）的识别、内化和降解。