ERRFI1,促分裂原诱导基因6蛋白/Mig-6抗体

产品编号HZ-14630R
英文名称ERRFI1
中文名称促分裂原诱导基因6蛋白/Mig-6抗体
别 名ERBB receptor feedback inhibitor 1; ERRFI_HUMAN; Errfi1; GENE 33; Gene 33, rat, homolog of; Mig6; MIG6; mitogen inducible gene 6; mitogen inducible gene 6 protein; Mitogen-inducible gene 6 protein; RALT; receptor-associated late transducer.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep,
ERRFI1,促分裂原诱导基因6蛋白/Mig-6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ERRFI1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ERRFI1,促分裂原诱导基因6蛋白/Mig-6抗体PubMedPubMed
产品介绍background:
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]

Function:
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

Subcellular Location:
Cytoplasm. Cell membrane. Nucleus. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.

Tissue Specificity:

ERRFI1,促分裂原诱导基因6蛋白/Mig-6抗体Similarity:
Belongs to the MIG6 family.

Gene ID:
54206

Database links:
Entrez Gene: 54206 Human
Omim: 608069 Human
SwissProt: Q9UJM3 Human
Unigene: 605445 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.