PCDHA3,原钙粘附蛋白α3抗体

产品编号HZ-11117R
英文名称PCDHA3
中文名称原钙粘附蛋白α3抗体
别 名KIAA0345 like 11; PCDH alpha 3; Protocadherin alpha 3; PCDA3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞外基质 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse,
PCDHA3,原钙粘附蛋白α3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量99kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PCDHA3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCDHA3,原钙粘附蛋白α3抗体PubMedPubMed
产品介绍background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA3 (Protocadherin alpha-3) is a 950 amino acid single-pass transmembrane protein that contains six cadherin domains. PCDHA3 is a unique cadherin in that it likely functions in spermatogenesis and may also have a role in organizing germ cell-specific structures, such as the flagellum, acrosome and intercellular bridge. There are two isoforms of PCDHA13 that are produced as a result of alternative splicing events.

Function:
PCDHA3 contains six cadherin domains. It is thought to be a calcium dependent cell adhesion protein and may be involved in the establishment and maintenance of specific neuronal connections in the brain. There are two named isoforms.

Subcellular Location:
Cell membrane; Single pass type I membrane protein.

Similarity:
Contains 6 cadherin domains.

Gene ID:
56145

Database links:
Entrez Gene: 56145 Human
Entrez Gene: 192163 Mouse
Entrez Gene: 116780 Rat
Omim: 606309 Human
SwissProt: Q9Y5H8 Human

PCDHA3,原钙粘附蛋白α3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.