DBC1,膀胱癌缺失基因1抗体

产品编号HZ-2761R
英文名称DBC1
中文名称膀胱癌缺失基因1
别 名Deleted in bladder cancer protein 1; deleted in bladder cancer protein 1 precursor; IB3089A; DBC1; DBCCR1; FAM5A; deleted in bladder cancer protein 1 homolog precursor; BMP/retinoic acid-inducible neural-specific protein 1; BRINP; Brinp1; LOC140610; DBC 1; DBC.1; DBCCR1; Deleted in bladder cancer chromosome region candidate 1; Deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; FAM5A; KIAA1967; OTTHUMP00000022751; p30 DBC; p30 DBC protein; Protein FAM5A; DBC1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
DBC1,膀胱癌缺失基因1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量86kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DBC1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DBC1,膀胱癌缺失基因1抗体PubMedPubMed
产品介绍background:
This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq].

Function:
Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.

Similarity:
Belongs to the FAM5 family.
Contains 1 MACPF domain.

Gene ID:
1620

Database links:
Entrez Gene: 1620 Human
Entrez Gene: 56710 Mouse
Entrez Gene: 140610 Rat
Omim: 602865 Human
SwissProt: O60477 Human
SwissProt: Q920P3 Mouse
SwissProt: Q925T8 Rat

DBC1,膀胱癌缺失基因1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.