DUSP5 (C-term) Peptide
产品名称: DUSP5 (C-term) Peptide
英文名称: DUSP5 (C-term) Peptide
产品编号: P3277
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP5.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DUSP5.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
Mandl M, Slack DN, Keyse SM.Mol Cell Biol. 2005 Mar;25(5):1830-45.
- 2.
- Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53.
Ueda K, Arakawa H, Nakamura Y.Oncogene. 2003 Aug 28;22(36):5586-91.
- 3.
- Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines.
Kwak SP, Dixon JE.J Biol Chem. 1995 Jan 20;270(3):1156-60.
- Entrez GeneID:
- 1847
- Protein Accession#:
- NP_004410
- Gene Name:
- DUSP5
- Gene Alias:
- DUSP,HVH3
- Gene Description:
- dual specificity phosphatase 5
- Omim ID:
- 603069
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq
- Other Designations:
- OTTHUMP00000020476,VH1-like phosphatase 3,serine/threonine specific protein phosphatase
- Gene Pathway