NCOA4 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
NCOA4 抗体

NCOA4 抗体

商家询价

产品名称： NCOA4 抗体

英文名称： NCOA4 Antibody

产品编号： XY 10968-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 NCOA4 抗体Applications

In-house applications ELISA     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
 
Recommended dilution  
 NCOA4 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen NCOA4 fusion protein ag1408 Full name Nuclear receptor coactivator 4
Calculated molecular
weight		 70 kDa Observed molecular 
weight		  
GenBank accession 
number		 BC012736 Gene ID (NCBI) 8031
Gene symbol NCOA4 Synonyms 70 kDa AR activator, ARA70, DKFZp762E1112, ELE1, NCoA 4, NCOA4, nuclear receptor coactivator 4, PTC3, Ret activating protein ELE1, RFG
Background NCOA4 抗体

Nuclear receptor coactivator 4 (NCOA4) also named androgen receptor (AR) coactivator ARA70, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome 10 in vivo. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. However, PPARg-ARA70 transactivation can be squelched by AR, which suggests cross talk between PPARg- and AR-mediated response. ARA70a has no intrinsic transcription activation domain or histone acetyltransferase activity, but it interacts with histone acetyltransferase, p/CAF, CBP and p300/CBP-associated factors, and the basal transcription factor TFIIB. The interaction between ARA70 and AR occurs through the ligand-binding domain. The presence of ARA70 can enhance the androgenic activity of 17-b Estradiol (E2) and antiandrogens toward AR. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.There are several isoforms of ZGPAT that are produced as a result of alternative splicing events. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b (The shorter variant, results from an internal 985-bp deletion.) is solely expressed in the testis.This antibody is a rabbit polyclonal antibody raised against the N-400aa of human NCOA4 protein. NCOA4 抗体

XY193Bo21 纤维蛋白原(FG)单克隆抗体 Monoclonal Antibody to Fibrinogen (FG) Bos taurus; Bovine (Cattle)

XY193Po21 纤维蛋白原(FG)单克隆抗体 Monoclonal Antibody to Fibrinogen (FG) Sus scrofa; Porcine (Pig)

XY193Ra21 纤维蛋白原(FG)单克隆抗体 Monoclonal Antibody to Fibrinogen (FG) Rattus norvegicus (Rat)

XY208Ra21 丙酮酸激酶(PK)单克隆抗体 Monoclonal Antibody to Pyruvate Kinase, Liver And RBC (PK) Rattus norvegicus (Rat)

XY212Ra21 基质金属蛋白酶23B(MMP23B)单克隆抗体 Monoclonal Antibody to klrix Metalloproteinase 23B (MMP23B) Rattus norvegicus (Rat)

XY213Po21 髓细胞触发受体1(TREM1)单克隆抗体 Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Sus scrofa; Porcine (Pig)

XY214Ca21 窖蛋白(CAV1)单克隆抗体 Monoclonal Antibody to Caveolin 1 (CAV1) Canis familiaris; Canine (Dog)

XY214Ga21 窖蛋白(CAV1)单克隆抗体 Monoclonal Antibody to Caveolin 1 (CAV1) Chicken (Gallus)

XY214Ra21 窖蛋白(CAV1)单克隆抗体 Monoclonal Antibody to Caveolin 1 (CAV1) Rattus norvegicus (Rat)

XY215Bo21 Ⅰ型胶原α2(COL1α2)单克隆抗体 Monoclonal Antibody to Collagen Type I Alpha 2 (COL1a2) Bos taurus; Bovine (Cattle)

XY215Ca21 Ⅰ型胶原α2(COL1α2)单克隆抗体 Monoclonal Antibody to Collagen Type I Alpha 2 (COL1a2) Canis familiaris; Canine (Dog)

XY215Rb21 Ⅰ型胶原α2(COL1α2)单克隆抗体 Monoclonal Antibody to Collagen Type I Alpha 2 (COL1a2) Oryctolagus cuniculus (Rabbit)

XY218Bo21 转化生长因子β2(TGFβ2)单克隆抗体 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) Bos taurus; Bovine (Cattle)

XY218Ca21 转化生长因子β2(TGFβ2)单克隆抗体 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) Canis familiaris; Canine (Dog)

XY218Ra21 转化生长因子β2(TGFβ2)单克隆抗体 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) Rattus norvegicus (Rat)

XY218Si21 转化生长因子β2(TGFβ2)单克隆抗体 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) Rhesus monkey (Simian)

XY220Bo21 肾上腺髓质素(ADM)单克隆抗体 Monoclonal Antibody to Adrenomedullin (ADM) Bos taurus; Bovine (Cattle)

XY220Ca21 肾上腺髓质素(ADM)单克隆抗体 Monoclonal Antibody to Adrenomedullin (ADM) Canis familiaris; Canine (Dog)