MYRIP,MYRIP蛋白抗体

产品编号HZ-11038R
英文名称MYRIP
中文名称MYRIP蛋白抗体
别 名exophilin 8; exophilin; Exophilin-8; Exophilin8; Myosin VIIA and Rab interacting protein; Myosin-VIIa- and Rab-interacting protein; MyRIP; MYRIP_HUMAN; rab effector MYRIP; SLAC 2C; SLAC2 C; SLAC2-C; SLAC2C; Slp homolog lacking C2 domains c; Slp homologue lacking C2 domains; Slp homologue lacking C2 domains c antibody Synaptotagmin like protein homologue lacking C2 domains c; synaptotagmin-like protein homologue lacking C2 domains-c.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
MYRIP,MYRIP蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量95kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MYRIP/SLAC2-C
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MYRIP,MYRIP蛋白抗体PubMedPubMed
产品介绍background:
Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton.

Function:
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments.

Subunit:
Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4.

Subcellular Location:
Cytoplasm. In pre- and post-synaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments.

Tissue Specificity:
Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.

Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain.

MYRIP,MYRIP蛋白抗体Database links:
Entrez Gene: 25924 Human
Entrez Gene: 245049 Mouse
Entrez Gene: 360034 Rat
Omim: 611790 Human
SwissProt: Q8NFW9 Human
SwissProt: Q8K3I4 Mouse
SwissProt: Q7TNY7 Rat
Unigene: 594535 Human
Unigene: 100936 Mouse
Unigene: 161974 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.