CX3CL1,CX3CL1抗体

产品编号HZ-0811R
英文名称CX3CL1
中文名称CX3CL1抗体
别 名C3Xkine; Chemokine C X3 C motif ligand 1; Chemokine CX3C Motif Ligand 1; CX3C membrane anchored chemokine; CXC 3; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; SCYD 1; SCYD1; Small inducible cytokine D1; Small inducible cytokine subfamily D (Cys X3 Cys) member 1; Small inducible cytokine subfamily D member 1; X3CL1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CX3CL1,CX3CL1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CX3CL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
CX3CL1,CX3CL1抗体PubMedPubMed
产品介绍background:
CX3CL1 is a member of the delta chemokine subfamily that contains a unique CX3C cysteine motif near the N-terminal. Unlike other known chemokines, it is a type 1 membrane protein containing a chemokine domain tethered on a long mucin-like stalk. CX3CL1, a leukocyte chemoattractant, is expressed in various tissues including the brain, heart, lung, kidney, skeletal muscle, and testis. The expression is reported to be up-regulated in endothelial cells and microglia by inflammatory signals. CX3CR1, a specific receptor for fractalkine, mediates both leukocyte migration and adhesion.

Function:
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.

Subunit:
Monomer.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted.

CX3CL1,CX3CL1抗体Tissue Specificity:
Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.

Post-translational modifications:
A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the intercrine delta family.

Gene ID:
6376

Database links:
Entrez Gene: 6376 Human
Entrez Gene: 20312 Mouse
Entrez Gene: 89808 Rat
Omim: 601880 Human
SwissProt: P78423 Human
SwissProt: O35188 Mouse
SwissProt: O55145 Rat
Unigene: 531668 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经趋化蛋白cx3cl1免疫应答应答及细胞附着，参与细胞因子和趋化因子介导信号转导、免疫细胞趋化性、调控炎症应答反应、白细胞附着激活、正调控钙非依赖细胞附着。