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上海信裕生物科技有限公司
iASPP抗体

iASPP抗体

商家询价

产品名称: iASPP抗体

英文名称: iASPPAntibody

产品编号: XY18590-1

产品价格: null

产品产地: 中国/美国

品牌商标: XYbscience

更新时间: 2023-08-17T09:55:27

使用范围: WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 IASPP抗体

Applications
In-house applications ELISA, IHC, IF, IP, WB     Application not tested? Please see our Guarantee.
Species specificity Human, Rat, Mouse; other species not tested.
Images
Prev12NextView more validation data
  • 18590-1-AP;Breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 18590-1-AP(PPP1R13L antibody) at dilution of 1:100 (under 10x lens)
  • 18590-1-AP;Breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 18590-1-AP(PPP1R13L antibody) at dilution of 1:100 (under 40x lens)
  • 18590-1-AP;MCF-7Immunofluorescent analysis of MCF-7 cells, using PPP1R13L antibody 18590-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
  • 18590-1-AP;NIH/3T3 cellsNIH/3T3 cells were subjected to SDS PAGE followed by western blot with 18590-1-AP( PPP1R13L Antibody) at dilution of 1:1000
  • 18590-1-AP;PC-3 cellsIP Result of anti-PPP1R13L (IP:18590-1-AP, 4ug; Detection:18590-1-AP 1:1000) with PC-3 cells lysate 1040ug.
Positive WB detected in NIH/3T3 cells, Apoptosised HeLa cells, C6 cells, MCF7 cells, PC-3 cells
Positive IP detected in PC-3 cells
Positive IHC detected in Human breast cancer tissue
Positive IF detected in MCF-7 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100
 IASPP抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen IASPP fusion protein ag13273 Full name Protein phosphatase 1, regulatory (inhibitor) subunit 13 like
Calculated molecular
weight
89 kDa Observed molecular 
weight
110 kDa
GenBank accession 
number
BC064913 Gene ID (NCBI) 10848
Gene symbol PPP1R13L Synonyms IASPP, Inhibitor of ASPP protein, NKIP1, PPP1R13B like protein, PPP1R13BL, PPP1R13L, Protein iASPP, RAI, RelA associated inhibitor
Background IASPP抗体

Inhibitor of apoptosis-stimulating protein of p53 (iASPP), encoded by PPP1R13L gene, is often overexpressed in human cancers. The ASPP family includes three members, namely ASPP1, ASPP2, and iASPP, which are specific regulators of p53-, p63-, and p73-mediated apoptosis. ASPP1 and ASPP2 enhance the apoptotic function of p53, whereas iASPP specifically inhibits p53- mediated apoptosis. Overexpression of iASPP is associated with resistance to cisplatin-induced apoptosis and rediation therapy. iASPP plays a pivotal role in regulating cancer cell proliferation and tumor progression. This antibody could both recognize unphosphorylated and phosphorylated iASPP. IASPP抗体

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