FITC标记的抗粘附素抗体
产品名称： FITC标记的抗粘附素抗体
英文名称： Anti-FXYD5/Dysadherin/FITC
产品编号： HZ-14475R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FXYD5/Dysadherin/FITC Conjugated antibody
FITC标记的抗粘附素抗体
| 英文名称 | Anti-FXYD5/Dysadherin/FITC |
| 中文名称 | FITC标记的抗粘附素抗体 |
| 别 名 | Dysad; Dysadherin; FXYD 5; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; Fxyd5; FXYD5_HUMAN; FXYD5RIC; HSPC 113; HSPC113; IWU 1; IWU1; KCT 1; KCT1; Keratinocytes associated transmembrane protein 1; OIT 2; OIT2; PRO 6241; PRO6241; RIC. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞粘附分子 肿瘤细胞生物标志物 跨膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dysadherin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Subcellular Location: Membrane. Post-translational modifications: Glycosylated. Similarity: Belongs to the FXYD family. Database links: Entrez Gene: 53827 Human GenBank: NP_054883 Human Omim: 606669 Human SwissProt: Q96DB9 Human Unigene: 333418 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因编码小膜蛋白家族的成员，该家族共享35个氨基酸的特征序列域，从PFXYD序列开始，包含7个不变性和6个高度保守的氨基酸。家庭批准的人类基因命名为含有FXYD结构域的离子转运调节剂。小鼠FXYD5被称为RIC（与离子通道有关）。FXYD2，也称为Na，K-ATP酶的γ亚基，调节该酶的性质。FXYD1(磷酸化外膜)、FXYD2(γ)、FXYD3(MAT-8)、FXYD4(CHIF)和FXYD5(RIC)在实验性表达系统中均可诱导通道活性。已经为两个家族成员（FXYD1和FXYD2）建立了跨膜拓扑结构，其中N端位于细胞外，C端位于细胞质侧。该基因产物FXYD5是一种糖蛋白，其功能是上调趋化因子产生，并且通过其下调E-钙粘附素的能力参与减少细胞粘附。它还促进转移，并与多种癌症有关。选择性剪接导致多个转录变体。Kathleen J.