NFKBIB (Human) Recombinant Protein (P02)
产品名称: NFKBIB (Human) Recombinant Protein (P02)
英文名称: NFKBIB (Human) Recombinant Protein (P02)
产品编号: H00004793-P02
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human NFKBIB full-length ORF ( NP_002494.2, 1 a.a. - 356 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
- Theoretical MW (kDa):
- 64.2
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 4793
- GeneBank Accession#:
- NM_002503.3
- Protein Accession#:
- NP_002494.2
- Gene Name:
- NFKBIB
- Gene Alias:
- IKBB,TRIP9
- Gene Description:
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
- Omim ID:
- 604495
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
- Other Designations:
- -
- Interactome
- Related Disease
- Arthritis, Rheumatoid
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Connective Tissue Diseases
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Empyema, Pleural
- Fetal Diseases
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- HIV Infections
- Inflammation
- Lymphoma, Non-Hodgkin
- Musculoskeletal Diseases
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary