PCSK2,神经内分泌转化酶2抗体

产品编号HZ-11533R
英文名称PCSK2/Proprotein Convertase 2
中文名称神经内分泌转化酶2抗体
别 名KEX2 like endoprotease 2; KEX2-like endoprotease 2; NEC 2; NEC2; NEC2_HUMAN; Neuroendocrine convertase 2; PC2; PCSK2; Prohormone convertase 2; Proprotein convertase 2; Proprotein convertase subtilisin/kexin type 2; SPC2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
PCSK2,神经内分泌转化酶2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Proprotein Convertase 2 (201-300aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCSK2,神经内分泌转化酶2抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

Function:
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

Similarity:
Belongs to the peptidase S8 family. Furin subfamily.

Database links:
Entrez Gene: 5126 Human
Entrez Gene: 18549 Mouse
Omim: 162151 Human
SwissProt: P16519 Human
SwissProt: P21661 Mouse
Unigene: 315186 Human
Unigene: 294493 Mouse
Unigene: 447466 Mouse

PCSK2,神经内分泌转化酶2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.