KLRD1 monoclonal antibody, clone HP-3B1
产品名称： KLRD1 monoclonal antibody, clone HP-3B1
英文名称： KLRD1 monoclonal antibody, clone HP-3B1
产品编号： MAB4672
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native KLRD1.
- Immunogen:
- Native purified KLRD1 from cultured human NK-cells.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes a disulfide-linked dimer of 43 Kd subunits, which is termed Kp43 or CD94. The expression of CD94 molecule appears restricted to natural killer (NK) cells and to a T lymphocyte subpopulation (1,2) including a subset of gamma/delta+ T-cells, and some alphga/beta+ CD8+ CD56+ T-cells, mainly V gamma 2/Vdelta2 (3). On NK cells the antigen structure apparently functions as a receptor for HLA-B7 on target cells. This interaction is inhibiting cytolytic activity of the NK cells and protects the cells carrying HLA-By (4). The HP-3B1 MAb was initially selected for its capacity to inhibit IL2-dependent proliferation of NK-cells (1). Blocking the receptor on resting NK cells, triggers the Fc-dependent redirected lysis by these cells of HLA-B7 carrying target cells (4,5)
- Form:
- Lyophilized
- Isotype:
- IgG2a, kappa
- Storage Buffer:
- Lyophilized from PBS (1mg/mL BSA)
- Storage Instruction:
- Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.
Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP.Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2304-9. Epub 2006 Feb 7.
- 2.
- Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L.J Exp Med. 1994 Aug 1;180(2):545-55.
- 3.
- Stimulation of IL-2-activated natural killer cells through the Kp43 surface antigen up-regulates TNF-alpha production involving the LFA-1 integrin.
Aramburu J, Balboa MA, Rodriguez A, Melero I, Alonso M, Alonso JL, Lopez-Botet M.J Immunol. 1993 Oct 1;151(7):3420-9.
- Application Image
- Immunohistochemistry (Frozen sections)
- Flow Cytometry
- Entrez GeneID:
- 3824
- Gene Name:
- KLRD1
- Gene Alias:
- CD94
- Gene Description:
- killer cell lectin-like receptor subfamily D, member 1
- Omim ID:
- 602894
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- CD94 antigen