FITC标记的T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
产品名称： FITC标记的T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
英文名称： Anti-Tal1/FITC
产品编号： HZ-9428R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Tal1/FITC Conjugated antibody
FITC标记的T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
| 产品编号 | bs-9428R-FITC |
| 英文名称 | Anti-Tal1/FITC |
| 中文名称 | FITC标记的T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体 |
| 别 名 | bHLHa17; Class A basic helix-loop-helix protein 17; SCL antibody; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL-1; tal1; TAL1_HUMAN; TCL 5; TCL5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 干细胞 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tal1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors. Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Subcellular Location: Nucleus. Tissue Specificity: Leukemic stem cell. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 6886 Human Omim: 187040 Human SwissProt: P17542 Human Unigene: 705618 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TAL1的活化特征是人类T细胞急性淋巴细胞白血病的60%，这是该疾病中观察到的最频繁的功能突变。TAL1（也称为SCL）是一种丝氨酸磷蛋白和已知调节胚胎造血的碱性螺旋环螺旋转录因子。该转录因子与E2A和HEB/HTF4结合为异源二聚体，被称为E-盒的核苷酸序列基序。此外，通过Tal1的转基因共表达和酪蛋白kinase IIalpha的催化亚基加速了白血病发生，酪蛋白/苏氨酸蛋白激酶已知调节其他BHLH转录因子的活性。