ADAM17抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
ADAM17抗体

ADAM17抗体

商家询价

产品名称： ADAM17抗体

英文名称： ADAM17Antibody

产品编号： XY24620-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 ADAM17抗体

Applications
Tested Applications: ELISA, WB, IHC
Specificity Reaction: Human; Other species are not tested.Please decide the specificity by homology
Positive WB detected in U-937 cells
Positive IHC detected in Human pancreas cancer tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 ADAM17抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev1NextView more validation data
  • 24620-1-AP;U-937 cellsU-937 cells were subjected to SDS PAGE followed by western blot with 24620-1-AP( ADAM17 Antibody) at dilution of 1:600
  • 24620-1-AP;human pancreas cancer tissueImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 24620-1-AP( ADAM17 Antibody) at dilution of 1:200 (under 10x lens).
  • 24620-1-AP;human pancreas cancer tissueImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 24620-1-AP( ADAM17 Antibody) at dilution of 1:200 (under 40x lens).
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information ADAM17抗体
Immunogen: ADAM17 fusion protein ag18273 Full Name: ADAM metallopeptidase domain 17
Caculated Molecular
Weight:		 824aa,93 kDa Observed Molecular 
Weight:		 75 kDa
GenbankNo BC136783 GeneID: 6868
Symbol ADAM17 Synonyms ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme
Background

The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). ADAM17抗体

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