BAX monoclonal antibody, clone 6A7
产品名称： BAX monoclonal antibody, clone 6A7
英文名称： BAX monoclonal antibody, clone 6A7
产品编号： MAB1809
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of BAX.
- Immunogen:
- A synthetic peptide corresponding to amino acids 12-24 of Human BAX.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.08% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Nonionic detergents induce dimerization among members of the Bcl-2 family.
Hsu YT, Youle RJ.J Biol Chem. 1997 May 23;272(21):13829-34.
- 2.
- Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.
Hsu YT, Wolter KG, Youle RJ.Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3668-72.
- Application Image
- Immunoprecipitation
- Entrez GeneID:
- 581
- Gene Name:
- BAX
- Gene Alias:
- BCL2L4
- Gene Description:
- BCL2-associated X protein
- Omim ID:
- 600040
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
- Other Designations:
- apoptosis regulator BAX
- Interactome
- Related Disease
- Adenocarcinoma
- Ataxia Telangiectasia
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Colon cancer
- Colonic Neoplasms
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Genomic Instability
- Head and Neck Neoplasms
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Leukemia, chronic myeloid
- Leukemia, Lymphocytic, Chronic