FITC标记的高迁移率族蛋白N3抗体
产品名称： FITC标记的高迁移率族蛋白N3抗体
英文名称： Anti-HMGN3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HMGN3/FITC Conjugated antibody
FITC标记的高迁移率族蛋白N3抗体
| 英文名称 | Anti-HMGN3/FITC |
| 中文名称 | FITC标记的高迁移率族蛋白N3抗体 |
| 别 名 | DKFZp686E20226; FLJ42187; High mobility group nucleosomal binding domain 3; High mobility group nucleosome-binding domain-containing protein 3; HMGN3; HMGN3_HUMAN; OTTHUMP00000016772; OTTHUMP00000016773; PNAS 24; PNAS 25; PNAS24; PNAS25; Thyroid hormone receptor interacting protein 7; Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP 7; TRIP-7; TRIP7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 生长因子和激素 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HMGN3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Subcellular Location: Nucleus. Tissue Specificity: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. Similarity: Belongs to the HMGN family. Database links: Entrez Gene: 515652 Cow Entrez Gene: 100723034 Guinea pig Entrez Gene: 100069315 Horse Entrez Gene: 9324 Human Entrez Gene: 94353 Mouse Entrez Gene: 100512571 Pig Entrez Gene: 113990 Rat Entrez Gene: 492345 Zebrafish Omim: 604502 Human SwissProt: Q3ZBV4 Cow SwissProt: Q15651 Human SwissProt: Q9DCB1 Mouse SwissProt: Q66H40 Rat Unigene: 77558 Human Unigene: 244426 Mouse Unigene: 106652 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
甲状腺受体是调节多种特异性靶基因表达的依赖性转录因子。该基因编码的蛋白质结合甲状腺受体β，但仅在甲状腺的存在下。编码蛋白是HMGN蛋白家族的成员，被认为会降低核小体中染色质纤维的致密性，从而增强来自染色质模板的转录。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。[ RefSeq，2011月1日]