FITC标记的磷酸化Disabled 1抗体
产品名称： FITC标记的磷酸化Disabled 1抗体
英文名称： Anti-Phospho-Dab1 (Ser491)/FITC
产品编号： HZ-3116R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-Dab1 (Ser491)/FITC Conjugated antibody
FITC标记的磷酸化Disabled 1抗体
| 英文名称 | Anti-Phospho-Dab1 (Ser491)/FITC |
| 中文名称 | FITC标记的磷酸化Disabled 1抗体 |
| 别 名 | Dab1 (phospho Ser491); Dab1 (phospho S491); p-Dab1 (phospho Ser491); Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Dab1 around the phosphorylation site of Ser491 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1. Post-translational modifications: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling. Similarity: Contains 1 PID domain. Database links: Entrez Gene: 374083 Chicken Entrez Gene: 1600 Human Entrez Gene: 13131 Mouse Entrez Gene: 266729 Rat Entrez Gene: 692351 Zebrafish Omim: 603448 Human SwissProt: O75553 Human SwissProt: P97318 Mouse SwissProt: Q8CJH2 Rat Unigene: 477370 Human Unigene: 289682 Mouse Unigene: 206534 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
大脑皮层中多个神经元类型的层级组织是正常认知功能所必需的。在小鼠中，Dababel-1基因在脑发育中起着中心作用，引导皮层神经元迁移到先前形成的神经元以达到其适当的层。该基因与Dababel-1相似，并且该基因编码的蛋白被认为是与蛋白激酶通路相互作用的信号转导子，以调节发育中的大脑中的神经元定位。选择性地报道了该基因的剪接转录变体，但其全长性质尚未确定。[ RefSeq，JUL 2008 ]