FITC标记的紧密连接蛋白1抗体(C端)
产品名称： FITC标记的紧密连接蛋白1抗体(C端)
英文名称： Anti-Claudin 1/FITC
产品编号： HZ-0790R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Claudin 1/FITC Conjugated antibody
FITC标记的紧密连接蛋白1抗体(C端)
| 英文名称 | Anti-Claudin 1/FITC |
| 中文名称 | FITC标记的紧密连接蛋白1抗体(C端) |
| 别 名 | claudin; Claudin1; CLD 1; CLD1; CLDN 1; CLDN1; ILVASC; SEMP 1; SEMP1; Senescence associated epithelial membrane protein 1; Senescence associated epithelial membrane protein; CLD1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Sheep, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq]. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed, with highest levels in liver and kidney. Similarity: Belongs to the claudin family. Database links: Entrez Gene: 9076 Human Entrez Gene: 12737 Mouse Entrez Gene: 65129 Rat Omim: 603718 Human SwissProt: O95832 Human SwissProt: O88551 Mouse SwissProt: P56745 Rat Unigene: 439060 Human Unigene: 289441 Mouse Unigene: 24293 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Claudin 1蛋白是紧密连接区相关的转膜蛋白Claudin的家族成员，在构成紧密连接的完整膜蛋白中发挥着一定作用，目前多用于肿瘤方面的研究 |
紧密连接代表上皮或内皮细胞片中的一种细胞间粘附模式，在细胞周围形成连续的密封，并作为物理屏障，以防止溶质和水自由地通过细胞旁空间。这些连接由朝外的细胞质小叶中的一组连续的网络股组成，在朝内的细胞质外小叶上具有互补的沟槽。该基因编码的蛋白质是克劳丁家族的成员，是一个完整的膜蛋白和紧密连接链的组成部分。功能丧失突变导致新生儿鱼鳞病硬化性胆管炎综合征。[由RefSeq提供]。