CRBN 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
CRBN 抗体

CRBN 抗体

商家询价

产品名称： CRBN 抗体

英文名称： CRBN Antibody

产品编号： XY11435-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 CRBN 抗体

Applications
In-house applications ELISA, WB, IHC, IF     Application not tested? Please see our Guarantee.
Published applications IHC, WB Publications 7 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, mouse
Images
Prev1NextView more validation data
  • 11435-1-AP;mouse heart tissuemouse heart tissue were subjected to SDS PAGE followed by western blot with 11435-1-AP(CRBN antibody) at dilution of 1:1000
  • 11435-1-AP;human cervical cancerImmunohistochemical of paraffin-embedded human cervical cancer using 11435-1-AP(CRBN antibody) at dilution of 1:50 (under 10x lens)
  • 11435-1-AP;COLO 320 cellsImmunofluorescent analysis of COLO 320 cells using 11435-1-AP( CRBN Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in Mouse heart tissue, A375 cells, COLO 320 cells, human brain tissue, human heart tissue, mouse liver tissue
Positive IHC detected in Human cervical cancer tissue
Positive IF detected in COLO 320 cells, A375 cells
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200
CRBN 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen CRBN fusion protein ag1951 Full name Cereblon
Calculated molecular
weight		 442aa,51 kDa Observed molecular 
weight		 53 kDa
GenBank accession 
number		 BC017419 Gene ID (NCBI) 51185
Gene symbol CRBN Synonyms Cereblon, CRBN, DKFZp781K0715, MRT2A, Protein cereblon
BackgroundCRBN 抗体

CRBN plays an important role in assembly and surface expression of functional BK(Ca) channels. The mutation of human cereblon gene (CRBN) is related with mild mental retardation, and causes ARNSID (nonsyndromal intellectual disability) by distubing the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. CRBN is also identified as important thalidomide-binding protein for limb outgrowth in zebrafish and chicks. It can be detected a band above 51 kDa (maybe 55 kDa) in HT22 cells(PMID: 21232561).CRBN 抗体

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