MARCH11,膜相关环指蛋白11抗体

产品编号HZ-9345R
英文名称MARCH11
中文名称膜相关环指蛋白11抗体
别 名E3 ubiquitin-protein ligase MARCH11; MARCH-XI; March11; MARHB_HUMAN; Membrane associated ring finger (C3HC4) 11; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 通道蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
MARCH11,膜相关环指蛋白11抗体产品应用ELISA=1:500-1000 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MARCH11
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MARCH11,膜相关环指蛋白11抗体PubMedPubMed
产品介绍background:
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

Function:
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).

Subunit:
Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins (By similarity).

Subcellular Location:
Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity).

Similarity:
Contains 1 RING-CH-type zinc finger.

Gene ID:
441061

Database links:
Entrez Gene: 441061 Human
Omim: 613338 Human
SwissProt: A6NNE9 Human
Unigene: 662216 Human

MARCH11,膜相关环指蛋白11抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.