FITC标记的FRMD5蛋白抗体
产品名称： FITC标记的FRMD5蛋白抗体
英文名称： Anti-FRMD5/FITC
产品编号： HZ-8237R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FRMD5/FITC Conjugated antibody
FITC标记的FRMD5蛋白抗体
| 产品编号 | bs-8237R-FITC |
| 英文名称 | Anti-FRMD5/FITC |
| 中文名称 | FITC标记的FRMD5蛋白抗体 |
| 别 名 | FERM domain containing 5; FERM domain-containing protein 5; FLJ41022; FRMD5; FRMD5_HUMAN; MGC14161. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FRMD5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD5 (FERM domain-containing protein 5) is a 570 amino acid single-pass membrane protein that contains one FERM domain and exists as two alternatively spliced isoforms. The gene encoding FRMD5 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Similarity: Contains 1 FERM domain. Database links: Entrez Gene: 84978 Human Entrez Gene: 228564 Mouse Entrez Gene: 311362 Rat SwissProt: Q7Z6J6 Human SwissProt: Q6P5H6 Mouse Unigene: 578544 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FEM结构域的长度约为150个氨基酸，在许多细胞骨架相关蛋白中发现，如Ezrin、Rexin、MeSin和4.1（红细胞膜蛋白带4.1），它们在细胞骨架信号和膜动力学之间提供联系。FRMD5（FRM结构域包含蛋白5）是含有570个氨基酸的单程膜蛋白，其含有一个FEM结构域，并作为两个交替剪接的异构体存在。编码FRMD5的基因映射到人类15号染色体上，该基因包含700个以上的基因，并包含人类基因组的近3%。安吉曼综合征、Prader Willi综合征、Tay-Sachs病和马凡综合征均与15号染色体定位基因的缺陷有关。