FITC标记的脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
产品名称： FITC标记的脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
英文名称： Anti-PSTPIP2/FITC
产品编号： HZ-19580R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PSTPIP2/FITC Conjugated antibody
FITC标记的脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
| 英文名称 | Anti-PSTPIP2/FITC |
| 中文名称 | FITC标记的脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体 |
| 别 名 | Macrophage actin associated tyrosine phosphorylated protein; Macrophage actin-associated tyrosine-phosphorylated protein; MAYP; PPIP2_HUMAN; Proline serine threonine phosphatase interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 结合蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSTPIP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). Subunit: Homodimer (PubMed:19584923). Homotrimer PubMed:17964261). Interacts (via coiled-coil domain) with CD2AP, PTPN12 and PTPN18. Interacts (via SH3 domain) with ABL1 and WAS. Interacts (via SH3 and coiled-coil domains) with MEFV (via B-box zinc finger); the interaction allows binding of MEFV to PYCARD and facilitates formation of PYCARD pyroptosomes. Interacts with CD2, DNM2 and FASLG. Subcellular Location: Cell Membrane; peripheral membrane protein and Cytoplasmic (by similarity). Tissue Specificity: Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. Post-translational modifications: Dephosphorylated on Tyr-345 by PTPN18, this event negatively regulates the association of PSTPIP1 with SH2 domain-containing proteins as tyrosine kinase. Phosphorylation of Tyr-345 is probably required for subsequent phosphorylation at other tyrosine residues. Phosphorylation is induced by activation of the EGFR and PDGFR in a ABL1 dependent manner. The phosphorylation regulates the interaction with WAS and with MEFV (By similarity). DISEASE: PAPA syndrome (PAPAS) [MIM:604416]: Characterized by autosomal dominant inheritance of early-onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction. Similarity: Contains 1 F-BAR domain. Contains 1 SH3 domain. Database links: Entrez Gene: 9050 Human Entrez Gene: 19201 Mouse Entrez Gene: 307248 Rat SwissProt: Q9H939 Human SwissProt: Q99M15 Mouse Unigene: 567384 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
结合F-肌动蛋白。可能参与调节肌动蛋白细胞骨架（通过相似性）。