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上海信裕生物科技有限公司
SYVN1抗体

SYVN1抗体

商家询价

产品名称： SYVN1抗体

英文名称： SYVN1Antibody

产品编号： XY13473-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 SYVN1抗体Applications

In-house applications ELISA, WB, IHC, IP, IF     Application not tested? Please see our Guarantee.
Published applications WB Publications 4 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev12NextView more validation data
  • 13473-1-AP;HEK-293 cellsHEK-293 cells were subjected to SDS PAGE followed by western blot with 13473-1-AP(HRD1 antibody) at dilution of 1:1000
  • 13473-1-AP;mouse kidney tissueIP Result of anti-HRD1 (IP:13473-1-AP, 4ug; Detection:13473-1-AP 1:1000) with mouse kidney tissue lysate 7200ug.
  • 13473-1-AP;human kidney tissueImmunohistochemistry of paraffin-embedded human kidney tissue slide using 13473-1-AP( HRD1 Antibody) at dilution of 1:50 (under 10x lens)
  • 13473-1-AP;human kidney tissueImmunohistochemistry of paraffin-embedded human kidney tissue slide using 13473-1-AP( HRD1 Antibody) at dilution of 1:50 (under 40x lens)
  • 13473-1-AP;HepG2 cellsImmunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 13473-1-AP( HRD1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in HEK-293 cells, HepG2 cells, MDA-MB-453s cells, mouse kidney tissue, mouse ovary tissue, mouse pancreas tissue, mouse stomach tissue, NIH/3T3 cells, Raji cells, rat stomach tissue
Positive IP detected in Mouse kidney tissue
Positive IHC detected in Human kidney tissue
Positive IF detected in HepG2 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:50-1:500
 SYVN1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen SYVN1 fusion protein ag4267 Full name Synovial apoptosis inhibitor 1, synoviolin
Calculated molecular
weight		 617aa,68 kDa Observed molecular 
weight		 68-76 kDa
GenBank accession 
number		 BC030530 Gene ID (NCBI) 84447
Gene symbol SYVN1 Synonyms HRD1, KIAA1810, Synovial apoptosis inhibitor 1, SYVN1
Background SYVN1抗体

HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1) , KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171). SYVN1抗体

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