FITC标记的丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体
产品名称： FITC标记的丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体
英文名称： Anti-WNK3/FITC
产品编号： HZ-1945R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-WNK3/FITC Conjugated antibody
FITC标记的丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体
| 英文名称 | Anti-WNK3/FITC |
| 中文名称 | FITC标记的丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体 |
| 别 名 | Serine/threonine-protein kinase WNK3; WNK lysine deficient protein kinase 3; Protein kinase with no lysine 3; Protein kinase, lysine-deficient 3; Wnk3; RGD1563131; KIAA1566; PRKWNK 3; PRKWNK-3; PRKWNK3; Protein kinase lysine deficient 3; Protein kinase lysine-deficient 3; Serine/threonine-protein kinase WNK3; WNK 3; WNK3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 染色质和核信号 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 198kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human WNK3 protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: WNK3 (WNK lysine deficient protein kinase 3) belongs to the serine/threonine protein kinase family. It lacks the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. A conserved lysine in subdomain I is thought to provide this function. WNK3 activates Na-(K)-Cl cotransporters by increasing their phosphorylation and appears to be a crucial component of the kinase/phosphatase signaling pathway that coordinately regulates the Cl– influx and efflux branches of the SLC12A cotransporter family. Subunit: Interacts with WNK1 and WNK4. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific. Similarity: BBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 65267 Human Omim: 300358 Human SwissProt: Q9BYP7 Human Unigene: 92423 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Wnk3（WNK赖氨酸缺乏蛋白激酶3）属于丝氨酸/苏氨酸蛋白激酶家族。它缺乏几乎不变的催化赖氨酸在子域II，这是重要的结合ATP在催化位点。一个保守的赖氨酸在子域I被认为提供了这个功能。Wnk3通过增加磷酸化而激活Na（K）-Cl共转运蛋白，似乎是协调调节SLC12A共转运蛋白家族的Cl-内流和流出支路的激酶/***酶信号通路的重要组成部分。