FITC标记的细胞角蛋白3抗体
产品名称： FITC标记的细胞角蛋白3抗体
英文名称： Anti-CK3/FITC
产品编号： HZ-3646R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CK3/FITC Conjugated antibody
FITC标记的细胞角蛋白3抗体
| 英文名称 | Anti-CK3/FITC |
| 中文名称 | FITC标记的细胞角蛋白3抗体 |
| 别 名 | Cytokeratin 3; 65 kDa cytokeratin; CK 3; CK-3; CK3; Cytokeratin-3; Cytokeratin3; FLJ95909; K2C3_HUMAN; K3; K3; Keratin 3; Keratin; Keratin type II cytoskeletal 3; Keratin-3; Keratin3; KRT 3; KRT3; type II cytoskeletal 3; Type-II keratin Kb3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 细胞类型标志物 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CK3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] Subunit: Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12. Tissue Specificity: Cornea specific. DISEASE: Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 281267 Cow Entrez Gene: 3850 Human Omim: 148043 Human SwissProt: P12035 Human SwissProt: Q29426 Rabbit Unigene: 680652 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白是角蛋白基因家族的成员。II型细胞角蛋白由基本或中性蛋白质组成，它们排列成对在简单和分层上皮组织分化过程中共表达的异型角蛋白链。这种II型细胞角蛋白在角膜上皮中与家族成员KRT12特异表达，这些基因的突变与Meesman角膜营养不良有关。II型细胞角蛋白聚集在染色体12q12～q13的一个区域。[ RefSeq，JUL 2008 ]