FITC标记的ZRANB3蛋白抗体
产品名称： FITC标记的ZRANB3蛋白抗体
英文名称： Anti-ZRANB3/FITC
产品编号： HZ-16407R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZRANB3/FITC Conjugated antibody
FITC标记的ZRANB3蛋白抗体
| 英文名称 | Anti-ZRANB3/FITC |
| 中文名称 | FITC标记的ZRANB3蛋白抗体 |
| 别 名 | 4933425L19Rik; MGC105033; MGC75012; OTTHUMP00000197449; Zinc finger Ran-binding domain-containing protein 3; Zinc finger, RAN- binding domain containing 3; ZRAB3_HUMAN; Zranb3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 123kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZRANB3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc finger Ran-binding domain-containing protein 3 (ZRANB3) is a 1079 amino acid gene product that belongs to the SNF2/RAD54 helicase family. Other family members are known to be involved in DNA repair and mitotic recombination. This family of proteins often plays an active role in recombination processes in cooperation with other members of the RAD52 epistasis group. The ZRANB3 product contains one helicase ATP-binding domain, one helicase C-terminal domain and one RanBP2-type zinc finger. RanBP2-type zinc fingers mediate the helicase binding to RNA. Similar to other Ran-binding zinc finger proteins, ZRANB3 likely acts as a splice factor for alternative splicing events of pre-mRNA transcripts. ZRANB proteins may also interfere with constitutive 5'-splice site selection. Function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Subunit: Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin). Subcellular Location: Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. Similarity: Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 RanBP2-type zinc finger. Database links: Entrez Gene: 84083 Human SwissProt: Q5FWF4 Human Unigene: 658422 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锌指Ran结合结构域蛋白3(ZRANB3)是SNF2/RAD54螺旋酶家族的1079个氨基酸基因产物。其他家庭成员已知参与DNA修复和有丝分裂重组。该蛋白家族通常与RAD52上位组的其他成员合作在重组过程中发挥积极作用。ZRANB3产物含有一个解旋酶ATP结合结构域，一个解旋酶C-末端结构域和一个RANBP2型锌指。RANBP2型锌指介导了解旋酶与RNA的结合。与其他Ran结合锌指蛋白相似，ZRANB3可能作为前mRNA转录体选择性剪接事件的剪接因子。ZRANB蛋白也可能干扰构式5’剪接位点的选择。