GJB2 Pre-design Chimera RNAi
产品名称： GJB2 Pre-design Chimera RNAi
英文名称： GJB2 Pre-design Chimera RNAi
产品编号： H00002706-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens gap junction protein, beta 2, 26kDa (connexin 26) (GJB2), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_004004
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 2706
- Gene Name:
- GJB2
- Gene Alias:
- CX26,DFNA3,DFNB1,HID,KID,NSRD1,PPK
- Gene Description:
- gap junction protein, beta 2, 26kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq
- Other Designations:
- OTTHUMP00000018093,OTTHUMP00000018094,connexin 26,gap junction protein beta 2,gap junction protein, beta 2, 26kD (connexin 26)
- Related Disease
- Aminoglycoside-induced deafness
- Apraxias
- Attention Deficit Disorder with Hyperactivity
- Auditory Perception
- Auditory Threshold
- Cholesteatoma
- Chorioamnionitis
- Chromosome Aberrations
- Chromosome Deletion
- Chronic Disease
- Cleft Lip
- Cleft Palate
- Cognition
- Cytomegalovirus Infections
- Deafness
- Deafness
- Disease Progression
- Diseases in Twins
- Fetal Membranes, Premature Rupture