FITC标记的Kelch样蛋白36抗体
产品名称： FITC标记的Kelch样蛋白36抗体
英文名称： Anti-KLHL36/FITC
产品编号： HZ-9628R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KLHL36/FITC Conjugated antibody
FITC标记的Kelch样蛋白36抗体
| 产品编号 | bs-9628R-FITC |
| 英文名称 | Anti-KLHL36/FITC |
| 中文名称 | FITC标记的Kelch样蛋白36抗体 |
| 别 名 | Kelch like 36; Kelch like protein 36; kelch-like 36 (Drosophila); Kelch-like protein 36; KLH36_HUMAN; KLHL 36; KLHL-36. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLHL36/C16orf44 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed. Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Subunit: Interacts with CUL3. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. Database links: Entrez Gene: 79786 Human Entrez Gene: 234796 Mouse Entrez Gene: 498957 Rat SwissProt: Q8N4N3 Human SwissProt: Q8R124 Mouse SwissProt: Q66HD2 Rat Unigene: 578546 Human Unigene: 86446 Mouse Unigene: 139361 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C16ORF44是包含616个Kelch重复序列、一个BTB/POZ结构域和一个BTB/KelCH相关（背）结构域的六个氨基酸的蛋白质。C16ORF44被认为在蛋白质泛素化中起作用，并且可以作为E3泛素蛋白连接酶复合物的底物特异性适配器。E3连接酶接受来自E2泛素缀合酶的泛素残基，并立即将该残基转移到靶向降解的蛋白质。具体地说，C16ORF44与Cul-3相互作用，这是cullin家族成员参与参与泛素介导的蛋白水解的蛋白质选择性靶向的成员。由于选择性剪接事件，C16ORF44的两种异构体被表达。