FITC标记的结节漏斗肽TIP39抗体
产品名称： FITC标记的结节漏斗肽TIP39抗体
英文名称： Anti-TIP39/Tuberoinfundibular peptide/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TIP39/Tuberoinfundibular peptide/FITC Conjugated antibody
FITC标记的结节漏斗肽TIP39抗体
| 英文名称 | Anti-TIP39/Tuberoinfundibular peptide/FITC |
| 中文名称 | FITC标记的结节漏斗肽TIP39抗体 |
| 别 名 | TIP39; TIPF39; Tuberoinfundibular peptide of 39 residues. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIP39/Tuberoinfundibular peptide |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tuberoinfundibular peptide of 39 residues (TIP39) was initially identified as a neurotransmitter and agonist of the PTH2 receptor, which is expressed in the cardiovascular system. Accumulating evidence suggests that TIP39 may be the endogenous ligand of the parathyroid hormone 2 receptor. The vast majority of TIP39 containing neurons are localized in two regions, the subparafascicular area at the thalamic midbrain junction, and the medial paralemniscal nucleus in the rostral pons. In contrast to the restricted localization of TIP39 containing cell bodies, TIP39 containing fibers have a widespread distribution. Function: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Subunit: Ligand of high affinity for the PTH2 receptor (PTH2R). Subcellular Location: Secreted Tissue Specificity: Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. Similarity: Belongs to the parathyroid hormone family. Database links: Entrez Gene: 113091 Human Entrez Gene: 114640 Mouse SwissProt: Q96A98 Human SwissProt: Q91W27 Mouse Unigene: 339845 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
结核漏斗肽39个残基（TIP39）最初被鉴定为PTH2受体的神经递质和激动剂，在心血管系统中表达。越来越多的证据表明，TIP39可能是甲状旁腺2受体的内源性配体。含TIP39的神经元主要分布在丘脑中脑交界处的束旁亚区和头侧脑桥内侧系膜旁核两个区域。与含TIP39的细胞体的局限性定位相反，含TIP39的纤维具有广泛的分布。