IKBKG (phospho S31) polyclonal antibody
产品名称： IKBKG (phospho S31) polyclonal antibody
英文名称： IKBKG (phospho S31) polyclonal antibody
产品编号： PAB0492
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of IKBKG.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S31 of human IKBKG.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
Reiley W, Zhang M, Wu X, Granger E, Sun SC.Mol Cell Biol. 2005 May;25(10):3886-95.
- 2.
- The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
Wilson GM, Fielding AB, Simon GC, Yu X, Andrews PD, Hames RS, Frey AM, Peden AA, Gould GW, Prekeris R.Mol Biol Cell. 2005 Feb;16(2):849-60. Epub 2004 Dec 15.
- 3.
- X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival.
Nishikomori R, Akutagawa H, Maruyama K, Nakata-Hizume M, Ohmori K, Mizuno K, Yachie A, Yasumi T, Kusunoki T, Heike T, Nakahata T.Blood. 2004 Jun 15;103(12):4565-72. Epub 2004 Jan 15.
- Applications
- Western Blot (Tissue lysate)
- The IKBKG (phospho S31) polyclonal antibody (Cat # PAB0492) is used in Western blot to detect Phospho-IKBKG-S31 in mouse cerebellum tissue lysate.
- Western Blot (Cell lysate)
- IKBKG (phospho S31) polyclonal antibody (Cat # PAB0492). Western blot analysis of IKBKG expression in Jurkat.
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with IKBKG (phospho S31) polyclonal antibody (Cat # PAB0492) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 8517
- Protein Accession#:
- NP_003630;Q9Y6K9
- Gene Name:
- IKBKG
- Gene Alias:
- AMCBX1,FIP-3,FIP3,Fip3p,IKK-gamma,IP,IP1,IP2,IPD2,NEMO
- Gene Description:
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [supplied by RefSeq
- Other Designations:
- NFkappaB essential modulator,OTTHUMP00000026027,OTTHUMP00000026028,OTTHUMP00000026029,incontinentia pigmenti
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- MAPK signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Primary immunodeficiency
- Prostate cancer
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway