CACNG3,神经元电压门控钙通道γ3/L-type Ca++CP γ3抗体

产品编号HZ-12059R
英文名称CACNG3
中文名称神经元电压门控钙通道γ3/L-type Ca++CP γ3抗体
别 名CACNG 3; Cacng2; Calcium channel voltage dependent gamma subunit 3; Neuronal voltage gated calcium channel gamma 3 subunit; Voltage dependent calcium channel gamma 3 subunit; Voltage gated calcium channel gamma subunit; CCG3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 通道蛋白 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
CACNG3,神经元电压门控钙通道γ3/L-type Ca++CP γ3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CACNG3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CACNG3,神经元电压门控钙通道γ3/L-type Ca++CP γ3抗体PubMedPubMed
产品介绍background:
CACNG3 belongs to the PMP-22/EMP/MP20 family, CACNG subfamily. It is thought to stabilize the calcium channel in an inactivated (closed) state. CACNG3 is a candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.

Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Subunit:
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

CACNG3,神经元电压门控钙通道γ3/L-type Ca++CP γ3抗体Database links:
UniProtKB/Swiss-Prot: O60359.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.