ADCY3,腺苷酸环化酶3抗体

产品编号HZ-20272R
英文名称ADCY3
中文名称腺苷酸环化酶3抗体
别 名A cyclase III; AC3; adenylate cyclase 3; Adenylate cyclase type III; ADCY3_HUMAN; Adenylate cyclase type 3; ATP pyrophosphate-lyase 3; AC-III; Adenylate cyclase, olfactive type; AC3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
ADCY3,腺苷酸环化酶3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量126kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ADCY3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ADCY3,腺苷酸环化酶3抗体PubMedPubMed
产品介绍background:
The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc. The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins.

Function:
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.

Post-translational modifications:

DISEASE:

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

Gene ID:
109

ADCY3,腺苷酸环化酶3抗体Database links:
Entrez Gene: 109 Human
Entrez Gene: 104111 Mouse
Entrez Gene: 64508 Rat
Omim: 600291 Human
SwissProt: O60266 Human
SwissProt: Q8VHH7 Mouse
SwissProt: P21932 Rat
Unigene: 727540 Human
Unigene: 70546 Mouse
Unigene: 87800 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Lane 1: (mouse/tissue)Spleenlysatesprobed withADCY3Polyclonal Antibody, Unconjugated (Catalog #bs-20272R) at 1:300 overnight at 4ⅹC. Followed by a conjugated secondary antibody (Secondary Catalog #926-32211) at 1:10000 for 60 min at 37ⅹC.