FITC标记的转录因子SOX7抗体
产品名称： FITC标记的转录因子SOX7抗体
英文名称： Anti-SOX7/FITC
产品编号： HZ-20571R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SOX7/FITC Conjugated antibody
FITC标记的转录因子SOX7抗体
| 英文名称 | Anti-SOX7/FITC |
| 中文名称 | FITC标记的转录因子SOX7抗体 |
| 别 名 | MGC10895; SOX 7; SOX 7 transcription factor; sox7; SOX7 transcription factor; SOX7_HUMAN; SRY (sex determining region Y) box 7; SRY box 7; SRY sex determining region Y box 7; Transcription factor SOX 7; Transcription factor Sox-7; Transcription factor SOX7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 干细胞 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOX7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'. Subunit: Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. Similarity: Contains 1 HMG box DNA-binding domain. Contains 1 Sox C-terminal domain. Database links: Entrez Gene: 83595 Human Entrez Gene: 20680 Mouse Entrez Gene: 290317 Rat Omim: 612202 Human SwissProt: Q9BT81 Human SwissProt: P40646 Mouse Unigene: 709543 Human Unigene: 42162 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SOX基因包括与哺乳动物性别决定基因SRY相关的一系列基因。这些基因同样包含编码HMG-box结构域的序列，该结构域负责序列特异性DNA结合活性。Sox基因编码推测的转录调控因子，参与发育过程中细胞命运的决定以及不同发育过程的控制。Sox基因的高度复杂组群聚集了至少40个不同的位点，这些位点在不同的动物谱系中迅速分化。目前已鉴定出30个SOX基因。这个家族的成员已被证明在进化过程中是保守的，并且在动物发育过程中起着关键作用。有些人参与了人类疾病，包括性反转。