ALKBH5 (NM_017758) Human Recombinant Protein
产品名称: ALKBH5 (NM_017758) Human Recombinant Protein
英文名称: ALKBH5 (NM_017758) Human Recombinant Protein
产品编号: PH30255E1
产品价格: 0
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: null
安诺伦(北京)生物科技有限公司
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产品概述:Purified recombinant protein of Human alkB, alkylation repair homolog 5 (E.coli) (ALKBH5), Ala2-Ile201, with N-terminal His tag, expressed in E.coli, 50ug 蛋白长度:A DNA sequence encoding the region(Ala2-Ile201) of ALKBH5 表达系统:E. coli 种属:Human 标签类型:N-His 分子量:22.1 kDa 通用名:ALKBH5 总结:Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).[UniProtKB/Swiss-Prot Function] 形式:Liquid 浓度:>50 ug/mL as determined by microplate BCA method 纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液:50mM Tris, 8M Urea, pH8.0. 别名:ABH5; OFOXD; OFOXD1