VEGFB,血管内皮生长因子B抗体

产品编号HZ-10072R
英文名称VEGFB
中文名称血管内皮生长因子B
别 名Vascular endothelial growth factor B; VEGF B; VEGFB; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 生长因子和激素 激酶和磷酸酶 细胞膜受体 血管内皮细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig,
VEGFB,血管内皮生长因子B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human VEGFB
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
VEGFB,血管内皮生长因子B抗体PubMedPubMed
产品介绍background:
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1.

Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Subcellular Location:
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Post-translational modifications:
VEGF-B167 is O-glycosylated.

VEGFB,血管内皮生长因子B抗体Similarity:
Belongs to the PDGF/VEGF growth factor family.

Gene ID:
7423

Database links:
Entrez Gene: 7423 Human
Entrez Gene: 22340 Mouse
Entrez Gene: 89811 Rat
Omim: 601398 Human
SwissProt: P49765 Human
SwissProt: P49766 Mouse
SwissProt: O35485 Rat
Unigene: 78781 Human
Unigene: 15607 Mouse
Unigene: 198550 Rat

VEGFB,血管内皮生长因子B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.