IL6ST Pre-design Chimera RNAi
产品名称: IL6ST Pre-design Chimera RNAi
英文名称: IL6ST Pre-design Chimera RNAi
产品编号: H00003572-R04
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_175767
- Target Region:
- 3' Untranslated Region (3'UTR)
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 3572
- Gene Name:
- IL6ST
- Gene Alias:
- CD130,CDw130,GP130,GP130-RAPS,IL6R-beta
- Gene Description:
- interleukin 6 signal transducer (gp130, oncostatin M receptor)
- Omim ID:
- 600694
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- CD130 antigen,IL6ST nirs variant 3,OTTHUMP00000122545,gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form,gp130 transducer chain,interleukin 6 signal transducer,interleukin receptor beta chain,membrane glycoprotein gp130,oncostatin M
- Related Disease
- Arthritis, Rheumatoid
- Atherosclerosis
- Cardiovascular Diseases
- Celiac Disease
- Chronic Disease
- Coronary Disease
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Hyperandrogenism
- Hypertension
- Lymphoproliferative Disorders
- Metabolic Syndrome X
- Multiple Myeloma
- Myocardial Infarction
- Obesity
- Obesity