EPB41L5,EPB41L5蛋白抗体

产品编号HZ-14608R
英文名称EPB41L5
中文名称EPB41L5蛋白抗体
别 名Band 4.1-like protein 5; BE37; E41L5_HUMAN; Epb41l5; erythrocyte membrane protein band 4.1 like 5; KIAA1548.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit,
EPB41L5,EPB41L5蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量82kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EPB41L5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EPB41L5,EPB41L5蛋白抗体PubMedPubMed
产品介绍background:
FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. EPB41L5 (erythrocyte membrane protein band 4.1 like 5), also known as BE37 or YMO1, is a 733 amino acid cytoplasmic protein that contains one FERM domain, which it uses to bind CRB1 (crumbs homolog 1). EPB41L5 is a homolog of zebrafish 'mosaic eyes' (moe), and is widely expressed but found at highest levels in ovary, kidney and brain, and is known to colocalize with β-catenin. EPB41L5 may participate in tight junction positioning during the establishment of epithelial cell polarity, and exists as four alternatively spliced isoforms that are encoded by a gene located on human chromosome 2q14.2.

Function:
May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.

EPB41L5,EPB41L5蛋白抗体Subunit:
Interacts with MPP5, CRB2 and CRB3.

Subcellular Location:
Cytoplasm. Cell junction; adherens junction. Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker.

Tissue Specificity:

Similarity:
Contains 1 FERM domain.

Gene ID:
57669

EPB41L5,EPB41L5蛋白抗体Database links:
Entrez Gene: 57669 Human
Omim: 611730 Human
SwissProt: Q9HCM4 Human
Unigene: 369232 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.