FITC标记的G0/G1期开关调节蛋白2抗体
产品名称： FITC标记的G0/G1期开关调节蛋白2抗体
英文名称： Anti-G1switch 2/FITC
产品编号： HZ-8656R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-G1switch 2/FITC Conjugated antibody
FITC标记的G0/G1期开关调节蛋白2抗体
| 产品编号 | bs-8656R-FITC |
| 英文名称 | Anti-G1switch 2/FITC |
| 中文名称 | FITC标记的G0/G1期开关调节蛋白2抗体 |
| 别 名 | G0/G1 switch regulatory protein 2; G0/G1switch 2; G0s2; G0S2_HUMAN; OTTHUMP00000034644; Putative lymphocyte G0/G1 switch protein 2; RP1 28O10.2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G0/G1 switch protein 2 (1-50aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G0S2 is a 103 amino acid novel target of peroxisome proliferator-activated receptors (PPARs) and regulator of latent HIV. G0S2 may be involved in adipocyte differentiation and its expression is essential for committing cells to enter the G1 phase of the cell cycle. G0S2 contains a CpG-rich island and multiple sites for potential phosphorylation by casein kinase II and protein kinase C. The gene encoding G0S2 maps to human chromosome 1, which is the largest human chromosome. Chromosome 1 spans about 260 million base pairs and makes up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Function: Potential oncogene and regulator of latent HIV. Subunit: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. Subcellular Location: Mitochondrion. Tissue Specificity: Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. Database links: UniProtKB/Swiss-Prot: P27469. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
G0S2是过氧化物酶体增殖物激活受体（PPAR）和潜伏HIV调节因子的103个氨基酸新靶点。G0S2可能参与脂肪细胞的分化，其表达对于使细胞进入细胞周期G1期至关重要。G0S2含有富含CpG的岛和酪蛋白激酶II和蛋白激酶C的潜在磷酸化的多个位点。编码G0S2的基因映射到人类1号染色体，这是最大的人类染色体。1号染色体约2亿6000万个碱基对，占人类基因组的8%。在1号染色体上有大约3000个基因，并且考虑到大量的基因，也有大量的与染色体1相关的疾病。值得注意的是，罕见的衰老性疾病Hutchinson Gilford早老症与编码lamin A. Stickler综合征的LMNA基因有关，帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。染色体1的畸变在多种癌症中发现，包括头颈部癌、恶性黑色素瘤和多发性骨髓瘤。